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Melanotan I is a synthetic, linear α-melanocyte-stimulating hormone (α-MSH) analog with the sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂. It is primarily studied for its activity at melanocortin receptor 1 (MC1R) and its role in melanocortin receptor activation.

In vitro studies indicate that Melanotan I activates cAMP-dependent signaling pathways associated with pigmentation regulation and photoprotective responses. As a research compound, it is commonly used in receptor pharmacology and cell-signaling investigations examining peptide–GPCR interactions and downstream transcriptional regulation under controlled laboratory conditions.

For research use only. Not intended for human or animal use.